北海道大学大学院保健科学研究院病態解析学分野

病理・免疫検査学研究室

Pathology and Immunology Labo, Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University

お問い合わせ

011-706-3385

論文発表

2021

原著論文

  1. Nishibata Y, Koshimoto S, Ogaki K, Ishikawa E, Wada K, Yoshinari M, Tamura Y, Uozumi R, Masuda S, Tomaru U, Ishizu A. RNase in the saliva can affect the detection of severe acute respiratory syndrome coronavirus 2 by real-time one-step polymerase chain reaction using saliva samples. Pathol Res Pract (in press)
  2. Kawakami T, Tamura Y, Dong Y, Yoshinari M, Nishibata Y, Masuda S, Tomaru U, Ishizu A. Anti-phosphatidylserine/prothrombin complex antibodies in patients with cutaneous vasculitis: possible involvement in the pathogenesis. J Dermatol 48(5):703-706, 2021.
  3. Kiuchi T, Tomaru U, Ishizu A, Imagawa M, Iwasaki S, Suzuki A, Otsuka N, Ohhara Y, Kinoshita I, Matsuno Y, Dosaka-Akita H, Kasahara M. Expression of the immunoproteasome subunit β5i in non–small cell lung carcinomas. J Clin Pathol 74(5): 300-306, 2021.
  4. Yamaguchi N, Tomaru U, Kiuchi T, Ishizu A, Deguchi T, Otsuka N, Satoshi, Tanaka S, Marukawa K, Matsuno Y, Kitagawa M, Kasahara M. Expression of cathepsin B, D, and K in thymic epithelial tumors. J Clin Pathol 74(2): 84-90, 2021.
  5. Tomaru U, Ito T, Ohmura Y, Higashikawa K, Miyajima S, Tomatsu R, Higashi T, Ishizu A, Kuge Y, Yoshioka M, Kasahara M. Decreased proteasomal function induces neuronal loss and memory impairment. Am J Pathol 191(1): 144-156, 2021.

総説・解説,症例報告

  1. Iwasaki S, Watanabe T, Tsuji T, Otsuka T, Makita K, Fukasawa Y, Ishizu A. Infliximab-induced granulomatous vasculitis with amyloid deposition in the tongue of a patient with Behçet’s disease. J Clin Rheumatol (in press)
  2. Ota H, Sato C, Igarashi A, Inoue S, Masuda S, Ishizu A, Watanabe M. Spontaneously regressed granulomatosis with polyangiitis: a case report. Respiratory Invest 59(3): 372-376, 2021.

2020

原著論文

  1. Nonokawa M, Shimizu T, Yoshinari M, Hashimoto Y, Nakamura Y, Takahashi D, Asano T, Nishibata Y, Masuda S, Nakazawa D, Tanaka S, Tomaru U, Iwasaki N, Ishizu A. Association of neutrophil extracellular traps with the development of idiopathic osteonecrosis of the femoral head. Am J Pathol 190(11): 2282-2289, 2020.
  2. Tanimura S, Nishida M, Horie T, Kamishima T, Matsumoto H, Morimura Y, Nishibata Y, Masuda S, Nakazawa D, Tomaru U, Atsumi T, Ishizu A. Fluvastatin prevents the development of arthritis in env-pX rats via up- regulation of Rho GTPase-activating protein 12. Exp Mol Pathol 115: 104454, 2020.
  3. Kawakami T, Kikuchi A, Miyabe C, Ikeda T, Takeuchi S, Tamura Y, Nishibata Y, Masuda S, Nakazawa D, Tomaru U, Ishizu A. Relationship between lysosomal-associated membrane protein-2 and anti-phosphatidylserine/prothrombin complex antibody in pathogenesis of cutaneous vasculitis. Clin Exp Rheumatol 38(Suppl. 124): S161-S165, 2020.
  4. Uozumi R, Iguchi R, Masuda S, Nishibata Y, Nakazawa D, Tomaru U, Ishizu A. Pharmaceutical immunoglobulins reduce neutrophil extracellular trap formation and ameliorate the development of MPO-ANCA-associated vasculitis. Mod Rheumatol 30(3): 544-550, 2020.
  5. Ikeda T, Kawakami T, Arimura Y, Ishiguro N, Ishizu A, Ito F, Ito-Ihara T, Okiyama N, Ono S, Suzuki K, Sugawara K, Seishima M, Kodera M, Tanaka M, Hasegawa M, Furukawa F, Yamaguchi Y, Yoshizaki A, Revised committee for guidelines for the management of vasculitis and vascular disorders of the Japanese Dermatological Association. Survey of Japanese dermatological vasculitis specialists on cases of cutaneous arteritis (cutaneous polyarteritis nodosa). J Dermatol 47(5): 534-537, 2020.
  6. Watanabe-Kusunoki K, Nakazawa D, Kusunoki Y, Kudo T, Hattanda F, Nishio S, Masuda S, Tomaru U, Kondo T, Atsumi T, Ishizu A. Recombinant thrombomodulin ameliorates autoimmune vasculitis via immune response regulation and tissue injury protection. J Autoimmun 108: 102390, 2020.

総説・解説,症例報告

  1. Nakazawa D, Ishizu A. Immunothrombosis in Severe COVID-19. EBioMedicine 59: 102942, 2020.
  2. Watanabe-Kusunoki K, Nakazawa D, Ishizu A, Atsumi T. Thrombomodulin as a physiological modulator of intravascular injury. Front Immunol 11: 575890, 2020.
  3. Asano Y, Matsumoto Y, Miyazaki T, Ishizu A, Morizane S, Hayashi K, Yamamura Y, Hiramatsu S, Miyawaki Y, Morishita M, Ohashi K, Watanabe H, Sunahori-Watanabe K, Kawabata T, Sada KE, Makino H, Wada J. Simultaneous Development of IgA Vasculitis and Eosinophilic Granulomatosis with Polyangiitis. Mod Rheumatol Case Rep 4(1): 63-69, 2020.
  4. Isobe M, Amano K, Arimura Y, Ishizu A, Ito S, Kaname S, Kobayashi S, Komagata Y, Komuro I, Komori K, Takahashi K, Tanemoto K, Hasegawa H, Harigai M, Fujimoto S, Miyazaki T, Miyata T, Yamada H, Yoshida A, Wada T, Inoue Y, Uchida HA, Ota H, Okazaki T, Onimaru M, Kawakami T, Kinouchi R, Kurata A, Kosuge H, Sada KE, Shigematsu K, Suematsu E, Sueyoshi E, Sugihara T, Sugiyama H, Takeno M, Tamura N, Tsutsumino M, Dobashi H, Nakaoka Y, Nagasaka K, Maejima Y, Yoshifuji H, Watanabe Y, Ozaki S, Kimura T, Shigematsu H, Yamauchi-Takihara K, Murohara T, Momomura SI; JCS Joint Working Group. JCS 2017 Guideline on Management of Vasculitis Syndrome—Digest Version. Circ J 84(2): 299-359, 2020.

2019年

原著論文

  1. Nonokawa M, Suzuki K, Hayashi H, Nishibata Y, Masuda S, Nakazawa D, Tanaka S, Tomaru U, Ishizu A. Native myeloperoxidase is required to make the experimental vasculitis model. Arthritis Res Ther 21(1): 296, 2019.
  2. 川上民裕, 有村義宏, 池田高治, 石黒直子, 石津明洋, 伊藤吹夕, 猪原登志子, 沖山奈緒子, 小野さち子, 鈴木和男, 菅原弘二, 清島真理子, 小寺雅也, 田中麻衣子, 長谷川稔, 古川福実, 山口由衣, 吉崎 歩, 日本皮膚科学会 新血管炎・血管障害診療ガイドライン改訂委員会. 皮膚動脈炎(皮膚型結節性多発動脈炎)の全国アンケート調査結果. 日本皮膚科学会雑誌 129(9): 1901-1907, 2019.
  3. Horie T, Nishida M, Tanimura S, Kamishima T, Tamai E, Morimura Y, Nishibata Y, Masuda S, Nakazawa D, Tomaru U, Atsumi T, Ishizu A. Detection of increased vascular signal in arthritis-prone rats without joint swelling using superb microvascular imaging ultrasonography. Ultrasound Med Biol 45(8): 2086-2093, 2019.
  4. Hattanda F, Nakazawa D, Watanabe-Kusunoki K, Kusunoki Y, Shida H, Masuda S, Nishio S, Tomaru U, Atsumi T, Ishizu A. The presence of anti-neutrophil extracellular trap antibody in patients with microscopic polyangiitis. Rheumatology (Oxford) 58(7): 1293-1298, 2019.
  5. Suzuki A, Sakamoto S, Kurosaki A, Kurihara Y, Satoh K, Usui Y, Nanki T, Arimura Y, Makino H, Okada Y, Harigai M, Yamagata K, Sugiyama H, Dobashi H, Ishizu A, Tsuboi N, Usui J, Sada KE, Honma S. Chest high-resolution CT findings of microscopic polyangiitis: a Japanese first nationwide prospective cohort study. Am J Roentgenol 213: 104-114, 2019.
  6. Masuda S, Nonokawa M, Futamata E, Nishibata Y, Iwasaki S, Tsuji T, Hatanaka Y, Nakazawa D, Tanaka S, Tomaru U, Kawakami T, Atsumi T, Ishizu A. Formation and disordered degradation of neutrophil extracellular traps in necrotizing lesions of anti-neutrophil cytoplasmic antibody-associated vasculitis. Am J Pathol 189(4): 839-846, 2019.
  7. Nishibata Y, Masuda S, Nakazawa D, Tanaka S, Tomaru U, Nergui M, Jia X, Cui Z, Zhao MH, Nakabayashi K, Ishizu A. Epitope recognized by anti-glomerular basement membrane (GBM) antibody in a patient with repeated relapse of anti-GBM disease. Exp Mol Pathol 107: 165-170, 2019.
  8. Yamagata K, Usui J, Nagata M, Sugiyama H, Sada KE, Muso E, Harigai M, Amano K, Atsumi T, Fujimoto S, Yuzawa Y, Kobayashi M, Saito T, Ito T, Hirawa N, Homma S, Dobashi H, Tsuboi N, Ishizu A, Arimura Y, Makino H, Matsuo S; Research Committee of Intractable Renal Disease and the Research Committee of Intractable Vasculitis Syndrome of the Ministry of Health, Labour, and Welfare of Japan. Histopathological classification of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a nationwide Japanese prospective 2-year follow-up cohort study. Clin Exp Nephrol 23(3): 387-394, 2019.
  9. Tomaru U, Konno S, Miyajima S, Kimoto R, Onodera M, Kiuchi S, Murata S, Ishizu A, Kasahara M. Restricted Expression of the Thymoproteasome Is Required for Thymic Selection and Peripheral Homeostasis of CD8+ T Cells. Cell Rep 26(3): 639-651.e2, 2019.
  10. Morita S, Nakamaru Y, Nakazawa D, Suzuki M, Hoshino K, Fukuda A, Hattanda F, Kusunoki-Watanabe K, Tomaru U, Ishizu A, Homma A. The diagnostic and clinical utility of the myeloperoxidase-deoxyribonucleic acid complex as a biomarker in otitis media with antineutrophil cytoplasmic antibody-associated vasculitis. Otol Neurotol 40(2):e99-e106, 2019.

総説・解説,症例報告等

  1. 石津明洋*. 北海道大学における病理・免疫検査学教室の教育と研究. 臨床検査学教育 11(1): 46-48, 2019.
  2. Takahashi K, Nakamura J, Sakiyama S, Nakaya T, Sato T, Watanabe T, Ohira H, Makita K, Tomaru U, Ishizu A, Tsujino I. A histopathological report of a 16-year-old male with peripheral pulmonary artery stenosis and Moyamoya disease with a homozygous RNF213 mutation. Respir Med Case Rep 29: 100977, 2019.
  3. Watanabe T, Marumo Y, Ishizu A. Retinal vasculitis in primary Sjögren’s syndrome. Rheumatology (Oxford) 58(7): 1244, 2019.
  4. Watanabe-Kusunoki K, Abe N, Nakazawa D, Karino K, Hattanda F, Fujieda Y, Nishio S, Yasuda S, Ishizu A, Atsumi T. A case report dysregulated neutrophil extracellular traps in a patient with propylthiouracil-induced anti-neutrophil cytoplasmic antibody-associated vasculitis. Medicine (Baltimore) 98(17): e15328, 2019.
  5. Kawauchi M, Watanabe T, Hattori T, Suzuki A, Ishizu A, Jodo S. Eosinophilic granulomatosis with polyangiitis mimicking peripheral T-cell lymphoma, not otherwise specified. Sand J Rheumatol 48(2): 171-172, 2019.
  6. Nakazawa D, Masuda S, Tomaru U, Ishizu A. Pathogenesis and therapeutic interventions for ANCA-associated vasculitis. Nat Rev Rheumatol 15(2): 91-101, 2019.

2018年

原著論文

  1. Nishioka Y, Sonoda T, Shida H, Kusunoki Y, Hattanda F, Tanimura S, Uozumi R, Yamada M, Nishibata Y, Masuda S, Nakazawa D, Tomaru U, Atsumi T, Ishizu A. Detection of autoreactive type II NKT cells: a pilot study of comparison between healthy individuals and patients with vasculitis. Cytometry A 93(11): 1157-1164, 2018.
  2. Mori A, Nishioka Y, Yamada M, Nishibata Y, Masuda S, Tomaru U, Honma N, Moriyama T, Ishizu A. Brain-derived neurotrophic factor induces angiogenin secretion and nuclear translocation in human umbilical vein endothelial cells. Pathol Res Pract 214(4): 521-526, 2018.
  3. Futamata E, Masuda S, Nishibata Y, Tanaka S, Tomaru U, Ishizu A. Vanishing immunoglobulins: the formation of pauci-immune lesions in myeloperoxidase-antineutrophil cytoplasmic antibody-associated vasculitis. Nephron 138(4): 328-330, 2018.
  4. Morita S, Nakamaru Y, Nakazawa D, Hattanda F, Shida H, Kusunoki Y, Watanabe K, Masuda S, Hoshino K, Fukuda A, Homma A, Tomaru U, Ishizu A. Elevated level of myeloperoxidase-deoxyribonucleic acid complex in the middle ear fluid obtained from patients with otitis media associated with antineutrophil cytoplasmic antibody-associated vasculitis. Otol Neurotol 39(4):e257-e262, 2018.

総説・解説,症例報告等

  1. Hasegawa J, Wakai S, Kono M, Imaizumi Y, Masuda S, Ishizu A, Honda K. An autopsy case of myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis accompanied by cryoglobulinemic vasculitis affecting the kidney, skin, and gastrointestinal tract. Intern Med 57(18): 2739-2745, 2018.
  2. Shida,H, Hashimoto N, Kusunoki Y, Hattanda F, Ogawa Y, Hayashi T, Nakazawa D, Masuda S, Tomaru U, Ishizu A. Anti-neutrophil extracellular trap antibody in a patient with relapse of anti-neutrophil cytoplasmic antibody-associated vasculitis: a case report. BMC Nephrol 19(1): 145, 2018.
  3. Nishioka Y, Masuda S, Tomaru U, Ishizu A. CD1d-restricted type II NKT cells reactive with endogenous hydrophobic peptides. Front Immunol 9: 548, 2018.

2017年

2016年

2015年

2014年

2013年

2012年

お問い合わせ

011-706-3385